D150959
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D150959
Aldrich
1,1-Dimethylbiguanide hydrochloride
97%
| Synonym: | Metformin |
| CAS Number: | 1115-70-4 |
| Linear Formula: | NH2C(=NH)NHC(=NH)N(CH3)2 · HCl |
| Molecular Weight: | 165.62 |
| EC Number: | 214-230-6 |
| MDL number: | MFCD00012582 |
| PubChem Substance ID: | 24893460 |
Description
| Frequently Asked Questions | Live Chat and Frequently Asked Questions are available for this Product. |
| Biochem/physiol Actions | Metformin is an antidiabetic agent that reduces blood glucose levels and improves insulin sensitivity. Its metabolic effects, including the inhibition of hepatic gluconeogenesis, are mediated at least in part by activation of the LKB1-AMPK (AMP-activated protein kinase) pathway. Activation of this pathway also appears to be involved in the antiproliferative and proapoptotic actions of metformin in cancer cell lines. |
| Packaging | 5 g in glass btl |
Properties
| assay | 97% |
| mp | 223-226 °C(lit.) |
Safety
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xn |
| Risk Statements | 22-36/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | DU1800000 |
References
| reference | Towler, M.C., and Hardie, D.G., AMP-activated protein kinase in metabolic control and insulin signaling. Circ. Res. 100, 328-341, (2007) |
| Zakikhani, M., et al., , Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. Cancer Res. 66, 10269-10273, (2006) | |
| Isakovic, A., et al., , Dual antiglioma action of metformin: cell cycle arrest and mitochondria-dependent apoptosis. Cell. Mol. Life Sci. 64, 1290-1302, (2007) | |
| Shaw, R.J., et al., , The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310, 1642-1646, (2005) | |
| Leverve, X.M., et al., , Mitochondrial metabolism and type-2 diabetes: a specific target for metformin. Diabetes Metab. 29, 6S88-6S94, (2003) | |
| Merck | Merck 13,5963 |
| Aldrich MSDS 1, 758:C / Corp MSDS 1 (1), 1358:A / FT-IR 2 (1), 1393:A / IR-Spectra (2), 431:D / IR-Spectra (3), 487:G / RegBook 1 (1), 965:K / Structure Index 1, 150:D:4 |
